Myocardial fibrosis: biomedical research from bench to bedside
نویسندگان
چکیده
منابع مشابه
Myocardial fibrosis: biomedical research from bench to bedside
Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial myocardial collagen network that occur in response to cardiac ischaemic insults, systemic diseases, drugs, or any other harmful stimulus affecting the circulatory system or the heart itself. Myocardial fibrosis alters the architecture of the myocardium, facilitating the development of cardiac dys...
متن کاملLiver fibrosis -- from bench to bedside.
Liver fibrosis has evolved in the past 20 years from a pure laboratory discipline to an area of great bedside relevance to practicing hepatologists. This evolution reflects growing awareness notonlyof themolecularunderpinningsoffibrosis, but also of its natural history and methods of detection in chronic liver disease. These advances have culminated in clear evidence that cirrhosis can be rever...
متن کاملTranslational Antidote Research: A Bedside to Bench Tale
Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...
متن کاملFrom bench to bedside
Because the microcirculation has emerged as an important reanimation target, appropriate methods to monitor the microcirculatory function are crucial. Several teams have now succeeded in crossing this bridge from bench to bedside, but the choice of the tissues of interest remains a debate. The potential accessible vascular beds that doctors could use in reanimation strategies and the relationsh...
متن کاملFrom Bench to Bedside
Since the initial experiments nearly a decade ago, remarkable progress has been made in the field of vascular gene transfer, and trials with human subjects already are under way. The potential of vascular wall gene transfer as therapy for various vascular diseases is considerable.1,2 The purpose of this review is 2-fold: (1) to delineate the methods and principles underlying vascular gene trans...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Heart Failure
سال: 2017
ISSN: 1388-9842,1879-0844
DOI: 10.1002/ejhf.696